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According to Eric F. Bernstein, M.D., Clinical Associate Professor at the University of Pennsylvania School of Medicine, "Diflucan, in my opinion, is certainly not a first line treatment that I would use in my office for treating patients with rosacea. It can have toxicity and is not recommended.
Fluconazole is an anti-fungal agent and there have been trials using it, but in my opinion its not a first line agent for rosacea and I do not use it in my practice to treat patients with rosacea."
Source
The Patient's Guide to Rosacea
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