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Immune System and Rosacea
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Please note: In my book, Rosacea 101, (published in October 2007) in Chapter 3, What Causes Rosacea?, Theory 5, Immune System Disorder, you can read an updated version of what I wrote below which was used as part of the basis for this subject. My new book is a comprehensive basic rosacea 101 knowledge for rosacea newbies who want to learn about the conventional and alternative treatments for rosacea. |
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"It is suggested that altered immune function plays a significant role in the pathogenesis of the disease." source
Involvement of Immune Mechanisms in the Pathogenesis of Rosacea
Manna V, Marks R, Holt P.
Twenty-five patients with rosacea were compared with twenty-five control subjects for previous medical history and tests of immune function. Rosacea patients were found to have a higher incidence of disorders of the auto-immune type and were significantly more difficult to sensitize to DNCB than the controls. In addition, twelve of the rosacea patients and eleven other rosacea patients had biopsies which were examined by the direct immunofluorescence technique. In only five was the test negative. In the remainder deposits of IgM and/or IgG and/or complement were found at the dermo-epidermal junction and/or in the dermal collagen. Serum from the rosacea patients was also examined by the indirect technique and in six cases a circulating antinuclear antibody of IgM type was found. It is suggested that altered immune function plays a significant role in the pathogenesis of the disease.
PMID: 6213254 [PubMed - indexed for MEDLINE]
Br J Dermatol 1982 Aug;107(2):203-8 Related Articles, Books, > source
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