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Rosacea News Details
Necessary to perform individual bacterial cultures and antibiograms in rosaceans?
A new study on acne and rosacea patients concluded these findings:
CONCLUSIONS:
1. In the cases of acne vulgaris the majority of isolated bacteria from conjunctival sac included Streptococcus spp., Staphylococcus spp. and Enterobacteriaceae.
2. In the severe cases of rosacea the main bacteria found in conjunctival sac were S. aureus, S.pyogenes, P.aeruginosa, E. faecalis, A. baumanii, P. fluorescens.
3. Because of changeable drug-sensitivity of bacterial strains, it seems to be necessary to perform individual culture and antibiogram in every patient with inflammatory lesions, in particular in clinically severe and resistant to therapy cases of acne vulgaris and rosacea.
4. The higher frequency of the bacterial colonisations in the conjunctival sac in patients with acne vulgaris and rosacea can be a potential source of ocular infections in the cases of local and systemic disorders of protective mechanisms.
5. Estimation of bacterial flora and antibiotic sensitivity of bacteria isolated from conjunctival sac, the skin of the eyelids and skin lesions should be perform, especially when patients are prepared for eye surgery. more info
Psychosocial impact of rosacea
A new study, "Psychosocial impact of rosacea," says "It was demonstrated that in comparison to the control group, patients with rosacea are less satisfied with their lives, subjectively feel that they receive poor social support, develop great intensity of symptoms, have difficulty in functioning in everyday life, worse general health perception, along with a higher level of anxiety and depression." more info
Rosaceans Less Likely to Use Alternative Treatments for Rosacea?
The authors of a report say that "rosacea sufferers are much less likely to use complementary and alternative medicine compared to sufferers of psoriasis and other dermatological conditions" according to one source. If this were true then there surely wouldn't be hundreds of alternative treatments for rosacea and hundreds, if not thousands of rosaceans discussing alternative treatments for rosacea in various rosacea discussion groups and how they have tried conventional treatments offered by physicians that were wanting. Polls depend on who the poll is polling. If you are interested in reading the report, see below:
Br J Dermatol. 2008 May;158(5):1139-41. Epub 2008 Feb 16
Complementary and alternative medicine usage in rosacea.
McAleer MA, Powell FC.
Severe exacerbation of rosacea induced by cinnamon supplements
"The authors report a case of a 68-year-old Caucasian female with type 2 diabetes mellitus who experienced an acute exacerbation of her rosacea 2 weeks after self-initiating cinnamon oil pills to lower her blood sugar levels. Historically, cinnamon oil has been used for a variety of medicinal purposes, but recently the use of cinnamon oil in lowering blood glucose and cholesterol levels in patients with type 2 diabetes is being investigated and gaining popularity amongst the general population. The use of cinnamon has commonly produced cutaneous side effects of irritant or allergic contact dermatitis and been reported to have vasodilatory effects. Yet, there are no reports of cinnamon use triggering a rosacea exacerbation in the literature." source
Skin Test for Demodex
Another clinical study has revealed demodex as a factor to consider in evaluating patients and concluded:
"Demodicidosis should be included in the differential diagnosis of facial eruptions in patients receiving phototherapy." source >
http://tinyurl.com/6gdkzn
The good thing about this report is that it concludes what I have been saying that a differential diagnosis should be done by taking a skin test for demodex. Physicians don't do this. The assume that demodex plays an insignificant or minor role in rosacea and they don't perform this test.
Get CEU Credit for Learning About Rosacea!
CPhA 2007 Home Study Program
Acne Rosacea
More Than a Red Nose
Penny Miller, BSc(Pharm), MA(Ed)
This program has been approved for 2.25 CEUs by the Canadian Council on Continuing Education in Pharmacy
Bradykinin Inhibitor Patent for Rosacea
The present invention results from my discovery of a causal link between the activation of the bradykinin pathway and rosacea. Accordingly, the invention features a method of treating or preventing rosacea by administering a compound that inhibits a component or components of the bradykinin activation pathway. source
Olive Leaf Extract for Rosacea?
An anecdotal report suggests that Olive Leaf helps rosacea. I have decided to try a bottle and am currently adding 950 mg a day for 25 days to see if there is any results with this treatment. You may be interested in trying some yourself and can do so by clicking here.
Lymphangiogenesis and angiogenesis in non-phymatous rosacea.
There are no published data regarding the role of lymphangiogenesis in patients with non-phymatous rosacea. A new study reports a new understanding of rosacea pathogenesis and suggests that lymphatics are involved early in the pathogenesis of rosacea and do not constitute a late event. This is noteworthy. For more info click here.
Everything Old is New Again
Found this interesting treatment for rosacea in 1878:
"...she was ordered Aug. 6, 1878, a mixture containing sulphate of iron and sulphate of magnesia, and for local application an ointment of sulphur, four parts, cosmoline, ninety-two parts. This was followed by rapid improvement, and when seen again on Sept. 17, all trace of the eruption had disappeared, and she felt much stronger and better." source
Aframomum for Rosacea?
According to the Washington Post, Aframomum melegueta, a member of the ginger family may have some powerful anti-inflammatory properties. Ilya Raskin, a biochemist at Rutgers University's Biotechnology Center has developed '006' which is derivative compound that works in a similar way to the well-known anti-inflammatory drugs Vioxx, Celebrex and Bextra but, it is hoped, without their side effects, said Raskin and other scientists.
Raskin first became interested in Aframomum during an international effort to search for medicines from plants. "Aframomum contains compounds called gingerols, which are chemically similar to other anti-inflammatory compounds," he said. "That's what initially drew our attention to the plant, and was confirmed in the lab."
Ilic is a visiting scientist at Rutgers, which has patents pending on Aframomum-related discoveries. Rutgers has licensed those rights to Phytomedics, Raskin said.
Phytomedics has licensed cosmetic-only rights to Avon Products Inc. to manufacture skin-care products that contain Aframomum, said Tolo Fridlender, president of Phytomedics.
Avon scientist Xiaochun Luo said the cosmetic's development is based on what Luo calls Aframomum's superior ability to counteract skin irritation. Avon expects to release the products next spring or summer. source
In an online discussion of the discovery, science writer Cheryl Lyn Dybas, who specializes in medicine, biology and marine science, responded to a question asked by someone in Wheaton, Md:
Wheaton, Md.: Is aframomum effective in the treatment of inflammation due to rosacea? If so, will the new products from Avon be marketed for this purpose? Thank you.
Cheryl Lyn Dybas: Hello, scientists say that the new products from Avon will be marketed only as cosmetics at this time.
However, Aframomum well may be effective against the inflammation in rosacea. source
Diagnostic Test for Rosacea?
According to UCSD, "A diagnostic test for rosacea can be developed by identifying higher levels of these specific peptides, or the processed forms, in patients suspected of having rosacea, distinguishing it from other dermatological or autoimmune diseases." source
New Acne & Rosacea Society Formed
According to Skin and Aging a new Acne and Rosacea
Society has been formed.
A dedicated, varied group of dermatologists met recently at the American Academy of Dermatology annual meeting with a singular focus: elevating the understanding and treatment of acne and rosacea. Gathering for the first time, members of the newly established American Acne & Rosacea Society (AARS) met to discuss the group's goals and objectives and to hear an entertaining keynote address from renowned dermatologist Albert Kligman, M.D., Ph.D.
According to AARS President Guy Webster, M.D., Ph.D., "AARS was formed to promote research and education on the biology and treatment of acne. Although acne and rosacea are common diseases that make up a large part of daily dermatologic practice, the academic community pays little attention to them. "We aim to correct this imbalance by encouraging investigation and developing young investigators. Educational programs will be created to aid in resident training, and our meetings will provide a forum for presenting the latest research." In addition to Dr. Webster, other Executive Committee members include President-Elect Hilary Baldwin, M.D., and Lee Zane, M.D., who is s Secretary-Treasurer. Founding Society Chairmen include Dr. Kligman, as well as Dr. John Strauss, Dr. Peter Pochi, Dr. Alan Shalita and Dr. Jim Leyden.
The list of Founding Directors is equally impressive and includes the following:
Diane Berson, M.D., David Cohen, M.D., James Q. Del Rosso, D.O., Lawrence Eichenfield, M.D., Julie Harper, M.D., Mark Jackson, M.D., Sewon Kang, M.D., Anne Lucky, M.D., Leonard Swinyer, M.D., and Diane Thiboutot, M.D. If you're interested in learning more about this group or joining the AARS, contact Dr. Baldwin at hbaldwin@downstate.edu. The AARS has not yet set a date for its next meeting; however, this enthusiastic group is sure to have a lasting impact. "Our inaugural meeting was a happy collision of veteran researchers and young acne specialists, a sort of hybrid of the All-Star Game and the Hall of Fame all at once," says Dr. Webster. "With such a group assembled I expect great things to happen!" > source
Niacinamide-containing facial moisturizer improves skin barrier and benefits subjects with rosacea.
A growing body of literature suggests that some moisturizers can improve stratum corneum barrier function, as well as ameliorate dry skin. The clinical signs and symptoms of rosacea, which include increased facial skin dryness and sensitivity, suggest a possible role for such moisturizers as an adjuvant in the management of this condition. This randomized, investigator-blind, controlled observational study (N = 50) was designed to assess whether a niacinamide-containing facial moisturizer would improve the stratum corneum barrier and thus provide a clinical benefit to subjects with rosacea. Subjects with rosacea applied the test moisturizer to their face and to one forearm twice daily for 4 weeks. The other forearm remained untreated as a control. Barrier function on the forearms was assessed instrumentally and using a dimethyl sulfoxide (DMSO) chemical probe. Stratum corneum hydration also was measured instrumentally. The dermatologist investigator evaluated each subject's rosacea condition over the course of the study, and subjects self-assessed their facial skin condition at study end. Instruments provided objective measures of stratum corneum barrier function and hydration on the face. [source]
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Tea Tree Oil Kills Demodex in Ocular Rosacea
Rosacea: disturbed defense against brain overheating
Venous blood flow from the skin to the brain appears to be suppressed in rosacea, thus inhibiting selective brain cooling in hyperthermic conditions.
Publication:
Archives of Dermatological Research
Authors:
H. Brinnel, J. Friedel, M. Caputa, M. Cabanac, E. Grosshans
Publisher: Springer Berlin / Heidelberg
Issue: Volume 281, Number 1, Pages: 66 - 72
Excerpt:
Tympanic (Tty), esophageal (Tes), forehead, and hand skin temperatures, as well as the forehead evaporation rate were recorded in six men (four suffering from rosacea and two healthy controls) before, during, and after 1 h of warm bath (38°–39°C). During the last ...source
All Natural Green Tea EXTRACT Incorporated Cream
An all natural green tea extract incorporated cream discovered by Tanweer Syed, MD, PhD, an associate professor of dermatology at the University of San Francisco, California, who developed the tea extract, said that women randomized to receive the cream had a 70% improvement in rosacea compared to women in the placebo arm. According to a small study, patients with papulopustular rosacea respond to treatment with hydrophilic cream containing 2% polyphenone (green tea extract) -- in particular reducing significantly the mean inflammatory lesion count when compared to placebo. source
A new rosacea forum has been announced administered by Warren Stuart. Click here for more info.
Ocean Essence for Rosacea?
Ocean Essence Protective Concealing Cream and Ocean Essence Moisturizing Renewal Lotion has been released by Michael Kelly, M.D., Ph.D., Natural Rosacea Treatment. We will no douibt hear more soon.
SansRosa Pharmaceutical Development Inc., West Conshohocken, Pennsyvania, has received $250,000 from BioAdvance. [source] "San Rosa’s first product is a novel treatment for rosacea that will represent a breakthrough as the first effective therapy for this common, disfiguring condition...SansRosa’s first product is designed to address this unmet need by effectively treating the erythema. It is a new form of a compound previously approved for an unrelated disease. The product, designated SR101, when applied topically to skin affected by rosacea produces a local effect eliminating the redness and restoring normal skin color. SR101 will be a topical, once-a-day, rapid onset product that will minimize the possibility of side effects from systemic administration. The therapeutic potential of this compound has been documented in an initial pilot study initiated by an investigator at the Mayo Clinic." source SansRosa.com is registered but under construction. Dr. Nase is investigating. [source] This product is in 'Phase I Clinical Development.' [source] More on SR101.
Another Rosacea Diet Book?
Another Rosacea Diet Book has been announced at r-s. The author is unknown at this point but will no doubt surface. Emulation is flattering. I assure you that it is not written by Brady Barrows who wrote the first Rosacea Diet.
Neuropathic Rosacea Becomes Subtype 5?
Dr. Nase reports that Neuropathic Rosacea may become Subtype 5 in the 'official' classification of rosacea soon at this post. Dr. Nase has his own classification of rosacea in his book and the NRS has developed the 'official' classification of four subtypes. Traditionally there has been only three stages classified. Classifying rosacea is no doubt a good idea since there is so much confusion on rosacea and having a standardization of classifications brings everyone into unity.
Zieluton - New Medication for Rosacea?
Dr. Nase reports a new medication, Zieluton, for rosacea [source]. Why is this better? [source]
Few Scientists Study Rosacea
While a recent report from by Rebecca Bryant in an article in Dermatology Times noted that rosacea is "is a potential gold mine for researchers" the fact is that few scientists are researching rosacea. For more info click here.
New Annotated Research Guide to Rosacea Internet References
A new guide on rosacea was created for medical professionals, students, and members of the general public who want to conduct medical research using the most advanced tools available and spending the least amount of time doing so on the internet. What a novel idea. The book costs $48.95 and is available at amazon..
Rosacea Research & Development Institute
A non profit organization for rosacea research has been formed for rosaceans. For more info > http://irosacea.org
New Medical CD Guide for Rosacea
A new medical CD guide for rosacea is available entitled, 21st Century Complete Medical Guide to Rosacea and Related Disorders, Authoritative Government Documents, Clinical References, and Practical Information for Patients and Physicians (CD-ROM) by PM Medical Health News. For more info click here..
Bacteria with Mites Causes Rosacea?
Researchers have successfully demonstrated a possible role for bacteria associated with microscopic mites in the development of subtype 2 (papulopustular) rosacea, which is characterized by persistent redness with bumps (papules) and pimples (pustules). Many researchers have postulated that rosacea is a vascular disorder but mounting evidence suggests otherwise. The most significant statement of the research says,
"This indicates that the Bacillus bacteria found in the Demodex mite produce an antigen that could be responsible for the tissue inflammation associated with papulopustular rosacea,"
You may read the entire article by clicking here
Read an editorial on Demodex Mites
Antioxidant System Defect Hypothesis in Rosacea?
Summary
A possible link between superoxide dismutase activity and malondialdehyde level with the clinical manifestations of rosacea was investigated. We found differences in superoxide dismutase activities between mild rosacea (stages I and II) and severe involvement (stage III) groups, as well as between disease and control groups that were statistically significant (P < 0.05). In the mild involvement group (stages I and II), the superoxide dismutase activity was higher than in the control group (P < 0.05), while the malondialdehyde levels did not differ from the control.
In the severe involvement group (stage III), the superoxide dismutase activity was lower than in the control group (P < 0.05), and this was coupled to a raised level of malondialdehyde (P < 0.05). These findings clearly show that in the mild involvement phase of rosacea patients, superoxide dismutase activity was stimulated to protect the skin against reactive oxygen species so that the malondialdehyde levels were maintained. In contrast, in more severe disease, due to a decrease in the capacity of the antioxidant defence system, the malondialdehyde levels were increased. These findings support the 'antioxidant system defect hypothesis' in rosacea patients.
read the entire article by clicking here
Possible Link Between Breast Cancer and Long-term Antibiotic Use
Many are naturally concerned what the possible long-term risks are for using antibiotics for the treatment of rosacea. A recent study indicates that there is a possible link between breast cancer and long-term antibiotic use. Who knows what other risks are associated with the long-term use of antibiotic treatment? If you keep taking antibiotics for years you will find out what they are for you at any rate. Dr. Sy in a post at the R-K yahoo group commented on this recent study and quotes the Academy of Dermatology statement on the recent findings from this study and I quote the following paragraphs:
"...While the findings of this research indicate there may be an association between antibiotic use and breast cancer, reviewers of the study state that it provides many more questions than it does answers. The research indicated that women who took antibiotics for more than 500 days or who had more than 25 prescriptions in the course of a 17-year period more than doubled their risk if breast cancer compared with women who had not taken any antibiotics....
...According to the Centers for Disease Control and Prevention, the overuse of antibiotics by the public has dramatically increased in the past 10 years. Please use this opportunity to educate your patients about the proper use of these drugs in order to ensure their safety..."
You may read the source of Dr. Sy's post which is Michele at this url by clicking here
No Standard Validated Tools For Assessing the Severity of Rosacea or its Signs or Symptoms
An International Journal of Dermatology report indicates that "at present, there are no standard validated tools for assessing the severity of rosacea or its signs or symptoms."
For details click here
However, there may be a diagnositc test in the works. click here for more into.
Propionibacterium Acnes Possible Factor in Rosacea
Based on the theory that rosacea shares the same inflammatory features of acne, a recent study showed that, just as the combination of benzoyl peroxide 1 percent and clindamycin 5 percent gel is a powerful treatment modality for reducing Propionibacterium acnes levels, it also significantly reduces the papules and pustules of rosacea, according to Debra L. Breneman, M.D. ...."Benzaclin, once daily, was found to be well tolerated and effective in the reduction of papules and pustules in patients with rosacea," said Dr. Breneman. "This lends credence to the theory that P. acnes is a potential aggravating factor in rosacea. This gives dermatologists a very effective treatment for rosacea." Source > http://www.dermatologytimes.com/
Periostat as an Adjunctive Treatment for Rosacea
CollaGenex Pharmaceuticals Reports Positive Outcome of Phase 2 Clinical Study Evaluating Periostat as an Adjunctive Treatment for Rosacea.
For complete report > click here
Rosacea and Depression
It has been reported that rosaceans may report periods of depression from problems associated with this disease.
To read the full report written by Geoffrey Nase, PhD. >
http://groups.yahoo.com/group/rosacea-support/message/50822
Three Stages - Plewig and Kligman Classification of Rosacea
(Taken from their book, Acne and Rosacea, Second Edition, 1993)
Stage I: The erythema (redness) may persist for hours and days, hence the old term erthema congestivum (redness congestion). Erythema lasting only a few minutes is not early rosacea. Telangiectases becomes progressively prominent, forming sprays on the nose, nasolabial folds, checks, and glabella. Most of these patients complain of sensitive skin that stings, burns, and itches after application of a variety of cosmetics, especially certain fragrances and sunscreens. Trauma from abrasives and peeling agents readily induces long-lasting erythema, thus the facial skin is unusually vulnerable to chemical and physical stimuli.
Stage II: Inflammatory papules and pustules crop up and persist for weeks. Some papules show a small pustule at the apex, justifying the term papulopustular. The lesions are alway |
