The presence of small intestinal bacterial overgrowth (SIBO) in patients with rosacea has been investigated and the results of this study says, "We found an increased prevalence of SIBO in patients with rosacea compared to controls (40/60 vs 3/60, respectively, p<0.001). Oro-cecal transit time resulted significantly delayed in patients with SIBO than in controls (p<0.01). After SIBO eradication we obtained a complete recovery of cutaneous lesions in 17/20 (85%) and a relevant improvement in 2/20 (10%) patients, while those treated with placebo remained unchanged (14/16) or even worsened (2/16), (p<0,001). These latter patients were subsequently switched to rifaximin therapy with complete resolution of rosacea in 14/16 and significant improvement in the remaining 2 cases.
CONCLUSION: Our study shows the high prevalence of SIBO in patients with rosacea and emphasizes the clinical effectiveness of its eradication in inducing almost complete remission of cutaneous lesions."
SMALL INTESTINAL BACTERIAL OVERGROWTH IN ROSACEA: CLINICAL EFFECTIVENESS OF ITS ERADICATION.
United European Gastroenterology Week
You might notice that the above article says that "Patients positive for SIBO were randomized to receive rifaximin 1200 mg/die for 10 days or placebo...These latter patients were subsequently switched to rifaximin therapy with complete resolution of rosacea in 14/16 and significant improvement in the remaining 2 cases." Wikipedia says that Rifaximin is "a semisynthetic, rifamycin-based non-systemic antibiotic, meaning that the drug will not pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics....It is currently sold in the U.S. under the brand name Xifaxan by Salix Pharmaceuticals. It's also sold in Europe under the name Spiraxin and Zaxine.." Source
An EIR Report on SIBO says that according "to Dr. Leo Galland, a specialist in dysbiosis related illness, the best diet to aid in the treatment of SIBO is very similar to that used to treat yeast overgrowth. This being a diet free of simple sugars and grains/cereals and low in fruit and starchy vegetables depending on individual tolerance. This diet restricts the nutrition available for bacteria in the upper GI tract to proliferate and reduces the excess alcohols and organic acids that are produced as a result of bacterial fermentation."
Please note: In my book, Rosacea 101, (published in October 2007) in Chapter 24, Rosacea Diet, page 87, I have advocated reducing sugar and high carbohydrate in diet to reduce rosacea since 1999. You may want to read more about using diet treatment for rosacea since my book is a comprehensive knowledge base for conventional and alternative treatements for rosacea 'newbies' which is a must have for those who want in one book what they should know about rosacea. |
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More on Bacterial Overgrowth
EIR Report on Treatment for SIBO
SIBO Discussion
Another report in May 2008 says:
"This study demonstrated that rosacea patients have a significantly higher SIBO prevalence than controls. Moreover, eradication of SIBO induced an almost complete regression of their cutaneous lesions and maintained this excellent result for at least 9 months." source
